Publications - Saleh Lab

Articles focused specifically on our lab research:

Microbiome composition modulates the lethal outcome of Drosophila A virus infection

González R, Castelló-Sanjuán M, Romoli O, Blanc H, Kobayashi H, Nigg J, Saleh MC.

Cell Mol Life Sci . 2026 Jan 3. doi: 10.1007/s00018-025-06042-8.

PubMed Download

Persistent viral infections impact key biological traits in Drosophila melanogaster

Mauro Castelló-Sanjuán, Rubén González, Ottavia Romoli, Hervé Blanc, Jared C Nigg, Maria-Carla Saleh

PLoS Biol. 2025 Oct 9;23(10):e3003437. doi: 10.1371/journal.pbio.3003437. eCollection 2025 Oct.

PubMed Download

Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila.

Fletcher SJ, Bardossy ES, Tomé-Poderti L, Moss T, Mongelli V, Frangeul L, Blanc H, Verdier Y, Vinh J, Mukherjee S, Saleh MC.

Sci Adv. 2025 May 16;11(20):eadv1286. doi: 10.1126/sciadv.adv1286. Epub 2025 May 16.

PubMed Download

Viral infection disrupts intestinal homeostasis via Sting-dependent NF-κB signaling in Drosophila.

Nigg JC, Castelló-Sanjuán M, Blanc H, Frangeul L, Mongelli V, Godron X, Bardin AJ, Saleh MC. 

Curr Biol. 2024 Jul 8;34(13):2785-2800.e7. doi: 10.1016/j.cub.2024.05.009. Epub 2024 May 31.

PubMed Download

Limitations in harnessing oral RNA interference as an antiviral strategy in Aedes aegypti.

Romoli O, Henrion-Lacritick A, Blanc H, Frangeul L, Saleh MC. 

iScience. 2024 Feb 16;27(3):109261. doi: 10.1016/j.isci.2024.109261. eCollection 2024 Mar 15.

PubMed Download

Mosquito core viromes: do they exist?

Koh C, Saleh MC

 Trends Parasitol 2024 Jan; (): .

PubMed Download

Translating mosquito viromes into vector management strategies.

Koh C, Saleh MC

Trends Parasitol. 2023 Dec; 40(1):10-20.

PubMed Download

Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti.

Merkling SH, Crist AB, Henrion-Lacritick A, Frangeul L, Couderc E, Gausson V, Blanc H, Bergman A, Baidaliuk A, Romoli O, Saleh MC, Lambrechts L

Cell Rep 2023 Aug; 42(8): 112977.

PubMed Download

Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification.

Koh C, Frangeul L, Blanc H, Ngoagouni C, Boyer S, Dussart P, Grau N, Girod R, Duchemin JB, Saleh MC.

Elife. 2023 Jan 23;12:e82762. doi: 10.7554/eLife.82762.

PubMed Download

The origin of RNA interference: Adaptive or neutral evolution?

Torri A, Jaeger J, Pradeu T, Saleh MC.

PLoS Biol 2022 Jun; 20(6): e3001715.

PubMed Download

Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster.

Mongelli V, Lequime S, Kousathanas A, Gausson V, Blanc H, Nigg J, Quintana-Murci L, Elena SF, Saleh MC.

Nat Ecol Evol 2022 05; 6(5): 565-578.

PubMed Download

Innovative Toolbox for the Quantification of Drosophila C Virus, Drosophila A Virus, and Nora Virus.

Nigg JC, Mongelli V, Blanc H, Saleh MC.

J Mol Biol. 2021 Oct 19;:167308.

PubMed Download

Interactions of the Insect-Specific Palm Creek Virus with Zika and Chikungunya Viruses in Aedes Mosquitoes.

Koh C, Henrion-Lacritick A, Frangeul L, Saleh MC.

Microorganisms. 2021 Aug 3;9(8)

PubMed Download

Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts.

Rezelj VV, Carrau L, Merwaiss F, Levi LI, Erazo D, Tran QD, Henrion-Lacritick A, Gausson V, Suzuki Y, Shengjuler D, Meyer B, Vallet T, Weger-Lucarelli J, Bernhauerová V, Titievsky A, Sharov V, Pietropaoli S, Diaz-Salinas MA, Legros V, Pardigon N, Barba-Spaeth G, Brodsky L, Saleh MC, Vignuzzi M.

Nat Commun. 2021 Apr 16;12(1):2290.

PubMed Download

Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes.

Levi LI, Rezelj VV, Henrion-Lacritick A, Erazo D, Boussier J, Vallet T, Bernhauerová V, Suzuki Y, Carrau L, Weger-Lucarelli J, Saleh MC, Vignuzzi M.

PLoS Pathog. 2021 Feb;17(2):e1009110.

PubMed Download

The Interplay Between Viruses and RNAi Pathways in Insects.

Bonning BC, Saleh MC.

Annu Rev Entomol. 2021 Jan 7;66:61-79.

PubMed Download

Evidence For Long-Lasting Transgenerational Antiviral Immunity in Insects.

Mondotte JA, Gausson V, Frangeul L, Suzuki Y, Vazeille M, Mongelli V, Blanc H, Failloux AB, Saleh MC.

Cell Rep. 2020 Dec 15;33(11):108506.

PubMed Download

Chikungunya virus replication rate determines the capacity of crossing tissue barriers in mosquitoes.

Merwaiss F, Filomatori CV, Suzuki Y, Bardossy ES, Alvarez DE, Saleh MC.

J Virol. 2020 Nov 4:JVI.01956-20.

PubMed Download

Non-retroviral Endogenous Viral Element Limits Cognate Virus Replication in Aedes aegypti Ovaries.

Suzuki Y, Baidaliuk A, Miesen P, Frangeul L, Crist AB, Merkling SH, Fontaine A, Lequime S, Moltini-Conclois I, Blanc H, van Rij RP, Lambrechts L, Saleh MC.

Curr Biol. 2020 Jul 9:S0960-9822(20)30909-X.

PubMed Download

Differential Small RNA Responses against Co-Infecting Insect-Specific Viruses in Aedes albopictus Mosquitoes.

Frangeul L, Blanc H, Saleh MC, Suzuki Y.

Viruses. 2020 Apr 21;12(4).

PubMed Download

Tudor-SN Promotes Early Replication of Dengue Virus in the Aedes aegypti Midgut

Merkling SH, Raquin V, Dabo S, Henrion-Lacritick A, Blanc H, Moltini-Conclois I, Frangeul L, Varet H, Saleh MC, Lambrechts L.

iScience. 2020 Feb 21;23(2):100870.

PubMed Download

Viral Infection and Stress Affect Protein Levels of Dicer 2 and Argonaute 2 in Drosophila melanogaster

Torri A, Mongelli V, Mondotte JA, Saleh MC.

Front Immunol. 2020 Mar 4;11:362.

PubMed Download

Manipulating Mosquito Tolerance for Arbovirus Control.

Lambrechts L, Saleh MC.

Cell Host Microbe. 2019 Sep 11;26(3):309-313.

PubMed Download

Interview: Maria-Carla Saleh.

Saleh MC.

Cell Microbiol. 2019 Aug;21(8):e13061. doi: 10.1111/cmi.13061. Epub 2019 Jun 17. No abstract available.

PubMed Download

Immune priming and clearance of orally acquired RNA viruses in Drosophila.

Mondotte JA, Gausson V, Frangeul L, Blanc H, Lambrechts L, Saleh MC.

Nat Microbiol. 2018 Oct 29. dos: 10.1038/s41564-018-0265-9.

PubMed

Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects.

Poirier EZ, Goic B, Tomé-Poderti L, Frangeul L, Boussier J, Gausson V, Blanc H, Vallet T, Loyd H, Levi LI, Lanciano S, Baron C, Merkling SH, Lambrechts L, Mirouze M, Carpenter S, Vignuzzi M, Saleh MC.

Cell host & microbe. 2018; 23(3):353-365.e8.

PubMed Download

Antiviral Immune Response and the Route of Infection in Drosophila melanogaster.

Mondotte JA, Saleh MC.

Advances in virus research. 2018; 100:247-278.

PubMed Download

Individual co-variation between viral RNA load and gene expression reveals novel host factors during early dengue virus infection of the Aedes aegypti midgut.

Raquin V, Merkling SH, Gausson V, Moltini-Conclois I, Frangeul L, Varet H, Dillies MA, Saleh MC, Lambrechts L.

PLoS neglected tropical diseases. 2017; 11(12):e0006152.

PubMed Download

Uncovering the repertoire of endogenous flaviviral elements in Aedes mosquito genomes.

Suzuki Y, Frangeul L, Dickson LB, Blanc H, Verdier Y, Vinh J, Lambrechts L, Saleh MC.

J Virol. 2017 May 24. pii: JVI.00571-17. doi: 10.1128/JVI.00571-17.

PubMed Download

Histone-derived piRNA biogenesis depends on the ping-pong partners Piwi5 and Ago3 in Aedes aegypti.

Girardi E, Miesen P, Pennings B, Frangeul L, Saleh MC, van Rij RP.

Nucleic Acids Res. 2017 May 5;45(8):4881-4892. doi: 10.1093/nar/gkw1368.

PubMed Download

Bugs Are Not to Be Silenced: Small RNA Pathways and Antiviral Responses in Insects.

Mongelli V, Saleh MC.

Annu Rev Virol. 2016 Sep 29;3(1):573-589.

PubMed Download

R.I.P. dead bacteria, you will not be attacked.

Tomé-Poderti L, Saleh MC.

Nat Immunol. 2016 Sep 20;17(10):1138-1140. doi: 10.1038/ni.3562

PubMed Download

Virus-derived DNA drives mosquito vector tolerance to arboviral infection.

Goic B, Stapleford KA, Frangeul L, Doucet AJ, Gausson V, Blanc H, Schemmel-Jofre N, Cristofari G, Lambrechts L, Vignuzzi M, Saleh MC.

Nat Commun. 2016 Sep 1;7:12410. doi: 10.1038/ncomms12410.

PubMed Download

piRNA pathway is not required for antiviral defense in Drosophila melanogaster.

Petit M, Mongelli V, Frangeul L, Blanc H, Jiggins F, Saleh MC.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4218-27. doi:10.1073/pnas.1607952113. Epub 2016 Jun 29.

PubMed Download

Drosophila cells use nanotube-like structures to transfer dsRNA and RNAi machinery between cells.

Karlikow M, Goic B, Mongelli V, Salles A, Schmitt C, Bonne I, Zurzolo C, Saleh MC.

Sci Rep. 2016 Jun 3;6:27085. doi: 10.1038/srep27085.

PubMed Download

Editorial overview: Host-microbe interactions: viruses: Viral sensing and activation of immunity.

Saleh MC.

Curr Opin Microbiol. 2014 Aug;20:x-xi. doi: 10.1016/j.mib.2014.07.002. Epub 2014 Jul 24.

PubMed Download

RNAi and antiviral defense in Drosophila: setting up a systemic immune response.

Karlikow M, Goic B, Saleh MC.

Dev Comp Immunol. 2014 Jan;42(1):85-92. doi: 10.1016/j.dci.2013.05.004. Epub 2013 May 14.

PubMed Download

RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila.

Goic B, Vodovar N, Mondotte JA, Monot C, Frangeul L, Blanc H, Gausson V, Vera-Otarola J, Cristofari G, Saleh MC.

Nat Immunol. 2013 Apr;14(4):396-403. doi: 10.1038/ni.2542. Epub 2013 Feb 24.

PubMed Download

The DNA virus Invertebrate iridescent virus 6 is a target of the Drosophila RNAi machinery.

Bronkhorst AW, van Cleef KW, Vodovar N, Ince IA, Blanc H, Vlak JM, Saleh MC, van Rij RP.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):E3604-13. doi: 10.1073/pnas.1207213109. Epub 2012 Nov 14.

PubMed Download

Living with the enemy: viral persistent infections from a friendly viewpoint.

Goic B, Saleh MC.

Curr Opin Microbiol. 2012 Aug;15(4):531-7. doi: 10.1016/j.mib.2012.06.002. Epub 2012 Jul 5

PubMed Download

Arbovirus-derived piRNAs exhibit a ping-pong signature in mosquito cells.

Vodovar N, Bronkhorst AW, van Cleef KW, Miesen P, Blanc H, van Rij RP, Saleh MC.

PLoS One. 2012;7(1):e30861. doi: 10.1371/journal.pone.0030861. Epub 2012 Jan 24.

PubMed Download

Of Insects and Viruses: The Role of Small RNAs in Insect Defence.

Vodovar N, Saleh MC.

Advances in Insect Physiology 2012;42: 1-36. doi:10.1016/B978-0-12-387680-5.00001-X

PubMed Download

In silico reconstruction of viral genomes from small RNAs improves virus-derived small interfering RNA profiling.

Vodovar N, Goic B, Blanc H, Saleh MC.

J Virol. 2011 Nov;85(21):11016-21. doi: 10.1128/JVI.05647-11. Epub 2011 Aug 31.

PubMed Download

dsRNA uptake in adult Drosophila.

Obadia B, Saleh MC.

Methods Mol Biol. 2011;721:253-63. doi: 10.1007/978-1-61779-037-9_16.

PubMed Download

Viral small RNA cloning and sequencing.

Gausson V, Saleh MC.

Methods Mol Biol. 2011;721:107-22. doi: 10.1007/978-1-61779-037-9_6.

PubMed Download

RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila.

Mueller S, Gausson V, Vodovar N, Deddouche S, Troxler L, Perot J, Pfeffer S, Hoffmann JA, Saleh MC, Imler JL.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19390-5. doi: 10.1073/pnas.1014378107. Epub 2010 Oct 26.

PubMed Download

Antiviral immunity in Drosophila requires systemic RNA interference spread.

Saleh MC, Tassetto M, van Rij RP, Goic B, Gausson V, Berry B, Jacquier C, Antoniewski C, Andino R.

Nature. 2009 Mar 19;458(7236):346-50. doi: 10.1038/nature07712. Epub 2009 Feb 8.

PubMed Download

The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster.

van Rij RP, Saleh MC, Berry B, Foo C, Houk A, Antoniewski C, Andino R.

Genes Dev. 2006 Nov 1;20(21):2985-95

PubMed Download

The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing.

Saleh MC, van Rij RP, Hekele A, Gillis A, Foley E, O’Farrell PH, Andino R.

Nat Cell Biol. 2006 Aug;8(8):793-802. Epub 2006 Jul 23.

PubMed Download

RNA silencing in viral infections: insights from poliovirus.

Saleh MC, Van Rij RP, Andino R.

Virus Res. 2004 Jun 1;102(1):11-7.

PubMed Download

Articles related to our research collaboration with other labs:

Limited impact of the siRNA pathway on transposable element expression in Aedes aegypti.

Bergman A, Crist AB, Lopez-Maestre H, Blanc H, Castelló-Sanjuán M, Frangeul L, Varet H, Daron J, Merkling SH, Saleh MC, Lambrechts L.

BMC Biol. 2025 May 13;23(1):130. doi: 10.1186/s12915-025-02225-8.

PubMed Download

Molecular basis of RNA recombination in the 3’UTR of chikungunya virus genome.

Bardossy ES, Volpe S, Suzuki Y, Merwaiss F, Faraj S, Montes M, Saleh MC, Alvarez DE, Filomatori CV.

Nucleic Acids Res. 2024 Sep 9;52(16):9727-9744. doi: 10.1093/nar/gkae650.

PubMed Download

Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations.

Dabo S, Henrion-Lacritick A, Lecuyer A, Jiolle D, Paupy C, Ayala D, da Veiga Leal S, Badolo A, Vega-Rúa A, Sylla M, Akorli J, Otoo S, Lutomiah J, Sang R, Mutebi JP, Saleh MC, Rose NH, McBride CS, Lambrechts L.

PLoS Negl Trop Dis. 2024 Mar 25;18(3):e0011862. doi: 10.1371/journal.pntd.0011862. eCollection 2024 Mar.

PubMed Download

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito.

Chelsea Cereghino, Ferdinand Roesch, Lucía Carrau, Alexandra Hardy, Helder V Ribeiro-Filho , Annabelle Henrion-Lacritick, Cassandra Koh, Jeffrey M Marano, Tyler A Bates, Pallavi Rai, Christina Chuong, Shamima Akter , Thomas Vallet, Hervé Blanc, Truitt J Elliott, Anne M Brown, Pawel Michalak, Tanya LeRoith, Jesse D Bloom, Rafael Elias Marques, Maria-Carla Saleh, Marco Vignuzzi, James Weger-Lucarelli.

PLoS Pathogens, 2023, 19 (4), pp.e1010491.

PubMed Download

RNA recombination at Chikungunya virus 3’UTR as an evolutionary mechanism that provides adaptability.

Filomatori CV, Bardossy ES, Merwaiss F, Suzuki Y, Henrion A, Saleh MC, Alvarez DE.

PLoS Pathog. 2019 Apr 15;15(4):e1007706. doi: 10.1371/journal.ppat.1007706. eCollection 2019 Apr.

PubMed Download

Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes.

Passoni G, Langevin C, Palha N, Mounce BC, Briolat V, Affaticati P, De Job E, Joly JS, Vignuzzi M, Saleh MC, Herbomel P, Boudinot P, Levraud JP.

Dis Model Mech. 2017 Jul 1;10(7):847-857. doi: 10.1242/dmm.029231. Epub 2017 May 8.

PubMed Download

Mal de Río Cuarto Virus Infection Triggers the Production of Distinctive Viral-Derived siRNA Profiles in Wheat and Its Planthopper Vector.

de Haro LA, Dumón AD, Mattio MF, Argüello Caro EB, Llauger G, Zavallo D, Blanc H, Mongelli VC, Truol G, Saleh MC, Asurmendi S, Del Vas M.

Front Plant Sci. 2017 May 10;8:766. doi: 10.3389/fpls.2017.00766. eCollection 2017.

PubMed Download

Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity.

Soler-Bistué A, Mondotte JA, Bland MJ, Val ME, Saleh MC, Mazel D.

PLoS Genet. 2015 Apr 13;11(4):e1005156. doi: 10.1371/journal.pgen.1005156. eCollection 2015.

PubMed Download

Novel Drosophila viruses encode host-specific suppressors of RNAi.

van Mierlo JT, Overheul GJ, Obadia B, van Cleef KW, Webster CL, Saleh MC, Obbard DJ, van Rij RP.

PLoS Pathog. 2014 Jul 17;10(7):e1004256. doi: 10.1371/journal.ppat.1004256. eCollection 2014 Jul.

PubMed Download

A long-chain flavodoxin protects Pseudomonas aeruginosa from oxidative stress and host bacterial clearance.

Moyano AJ, Tobares RA, Rizzi YS, Krapp AR, Mondotte JA, Bocco JL, Saleh MC, Carrillo N, Smania AM.

PLoS Genet. 2014 Feb 13;10(2):e1004163. doi: 10.1371/journal.pgen.1004163. eCollection 2014 Feb.

PubMed Download

Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models.

Rozen-Gagnon K, Stapleford KA, Mongelli V, Blanc H, Failloux AB, Saleh MC, Vignuzzi M.

PLoS Pathog. 2014 Jan;10(1):e1003877. doi: 10.1371/journal.ppat.1003877. Epub 2014 Jan 16.

PubMed Download