As scientists we have an obligation to share our research and results in efforts of moving science forward. Below is a collection of our contributions to the scientific community. We are proud that our research has been featured in these leading, peer-reviewed journals.

Articles focused specifically on our lab research:

Mosquito core viromes: do they exist?
Koh C, Saleh MC
Trends Parasitol 2024 Jan; (): .

  PubMed   |     Download PDF

Translating mosquito viromes into vector management strategies.
Koh C, Saleh MC
Trends Parasitol. 2023 Dec; 40(1):10-20.

  PubMed   |     Download PDF

Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti.
Merkling SH, Crist AB, Henrion-Lacritick A, Frangeul L, Couderc E, Gausson V, Blanc H, Bergman A, Baidaliuk A, Romoli O, Saleh MC, Lambrechts L, Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti.
Cell Rep 2023 Aug; 42(8): 112977.

  PubMed   |     Download PDF

Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification.
Koh C, Frangeul L, Blanc H, Ngoagouni C, Boyer S, Dussart P, Grau N, Girod R, Duchemin JB, Saleh MC.
Elife. 2023 Jan 23;12:e82762. doi: 10.7554/eLife.82762.


The origin of RNA interference: Adaptive or neutral evolution?
Torri A, Jaeger J, Pradeu T, Saleh MC.
PLoS Biol 2022 Jun; 20(6): e3001715.


Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila

Mongelli V, Lequime S, Kousathanas A, Gausson V, Blanc H, Nigg J, Quintana-Murci L, Elena SF, Saleh

Nat Ecol Evol 2022 05; 6(5): 565-578.

  PubMed   |     Download PDF

Innovative Toolbox for the Quantification of Drosophila C Virus, Drosophila A Virus, and Nora Virus.
Nigg JC, Mongelli V, Blanc H, Saleh MC.
J Mol Biol. 2021 Oct 19;:167308.


Interactions of the Insect-Specific Palm Creek Virus with Zika and Chikungunya Viruses in Aedes Mosquitoes.
Koh C, Henrion-Lacritick A, Frangeul L, Saleh MC.
Microorganisms. 2021 Aug 3;9(8)


Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts.
Rezelj VV, Carrau L, Merwaiss F, Levi LI, Erazo D, Tran QD, Henrion-Lacritick A, Gausson V, Suzuki Y, Shengjuler D, Meyer B, Vallet T, Weger-Lucarelli J, Bernhauerová V, Titievsky A, Sharov V, Pietropaoli S, Diaz-Salinas MA, Legros V, Pardigon N, Barba-Spaeth G, Brodsky L, Saleh MC, Vignuzzi M.
Nat Commun. 2021 Apr 16;12(1):2290.


Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes.
Levi LI, Rezelj VV, Henrion-Lacritick A, Erazo D, Boussier J, Vallet T, Bernhauerová V, Suzuki Y, Carrau L, Weger-Lucarelli J, Saleh MC, Vignuzzi M.
PLoS Pathog. 2021 Feb;17(2):e1009110.


The Interplay Between Viruses and RNAi Pathways in Insects.
Bonning BC, Saleh MC.
Annu Rev Entomol. 2021 Jan 7;66:61-79.

  PubMed   |     Download PDF

Evidence For Long-Lasting Transgenerational Antiviral Immunity in Insects.
Mondotte JA, Gausson V, Frangeul L, Suzuki Y, Vazeille M, Mongelli V, Blanc H, Failloux AB, Saleh MC.
Cell Rep. 2020 Dec 15;33(11):108506.

PubMed   |    Open Access from Cell Reports website

Chikungunya virus replication rate determines the capacity of crossing tissue barriers in mosquitoes.
Merwaiss F, Filomatori CV, Suzuki Y, Bardossy ES, Alvarez DE, Saleh MC.
J Virol. 2020 Nov 4:JVI.01956-20.

PubMed   |    Open Access from JVI website

Non-retroviral Endogenous Viral Element Limits Cognate Virus Replication in Aedes aegypti Ovaries.
Suzuki Y, Baidaliuk A, Miesen P, Frangeul L, Crist AB, Merkling SH, Fontaine A, Lequime S, Moltini-Conclois I, Blanc H, van Rij RP, Lambrechts L, Saleh MC.
Curr Biol. 2020 Jul 9:S0960-9822(20)30909-X.

PubMed   |    Open access from Current Biology website

Differential Small RNA Responses against Co-Infecting Insect-Specific Viruses in Aedes albopictus Mosquitoes.
Frangeul L, Blanc H, Saleh MC, Suzuki Y.
Viruses. 2020 Apr 21;12(4).

PubMed   |    Open access from Viruses website

Tudor-SN Promotes Early Replication of Dengue Virus in the Aedes aegypti Midgut
Merkling SH, Raquin V, Dabo S, Henrion-Lacritick A, Blanc H, Moltini-Conclois I, Frangeul L, Varet H, Saleh MC, Lambrechts L.
iScience. 2020 Feb 21;23(2):100870.

PubMed   |    Open access from iScience website

Viral Infection and Stress Affect Protein Levels of Dicer 2 and Argonaute 2 in Drosophila melanogaster
Torri A, Mongelli V, Mondotte JA, Saleh MC.
Front Immunol. 2020 Mar 4;11:362.

PubMed   |   Open access from Frontiers website

Manipulating Mosquito Tolerance for Arbovirus Control.
Lambrechts L, Saleh MC.
Cell Host Microbe. 2019 Sep 11;26(3):309-313.

PubMed   |    Open access from CHM website

Interview: Maria-Carla Saleh.
Saleh MC.
Cell Microbiol. 2019 Aug;21(8):e13061. doi: 10.1111/cmi.13061. Epub 2019 Jun 17. No abstract available.

PubMed   |     Open access from Cellular Microbiology website

Immune priming and clearance of orally acquired RNA viruses in Drosophila.

Mondotte JA, Gausson V, Frangeul L, Blanc H, Lambrechts L, Saleh MC.

Nat Microbiol. 2018 Oct 29. dos: 10.1038/s41564-018-0265-9.

  PubMed   |     View-only PDF

Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects.
Poirier EZ, Goic B, Tomé-Poderti L, Frangeul L, Boussier J, Gausson V, Blanc H, Vallet T, Loyd H, Levi LI, Lanciano S, Baron C, Merkling SH, Lambrechts L, Mirouze M, Carpenter S, Vignuzzi M, Saleh MC.
Cell host & microbe. 2018; 23(3):353-365.e8.

PubMed   |     Open access from CHM website

Antiviral Immune Response and the Route of Infection in Drosophila melanogaster.
Mondotte JA, Saleh MC.
Advances in virus research. 2018; 100:247-278.

  PubMed   |     Download PDF

Individual co-variation between viral RNA load and gene expression reveals novel host factors during early dengue virus infection of the Aedes aegypti midgut.
Raquin V, Merkling SH, Gausson V, Moltini-Conclois I, Frangeul L, Varet H, Dillies MA, Saleh MC, Lambrechts L.
PLoS neglected tropical diseases. 2017; 11(12):e0006152.

PubMed   |     Open access from PLoS NTDS website

Uncovering the repertoire of endogenous flaviviral elements in Aedes mosquito genomes.
Suzuki Y, Frangeul L, Dickson LB, Blanc H, Verdier Y, Vinh J, Lambrechts L, Saleh MC.
J Virol. 2017 May 24. pii: JVI.00571-17. doi: 10.1128/JVI.00571-17. [Epub ahead of print]

PubMed   |     Open access from JVI website

Histone-derived piRNA biogenesis depends on the ping-pong partners Piwi5 and Ago3 in Aedes aegypti.
Girardi E, Miesen P, Pennings B, Frangeul L, Saleh MC, van Rij RP.
Nucleic Acids Res. 2017 May 5;45(8):4881-4892. doi: 10.1093/nar/gkw1368.

PubMed   |     Open access from NAR website

Bugs Are Not to Be Silenced: Small RNA Pathways and Antiviral Responses in Insects.
Mongelli V, Saleh MC.
Annu Rev Virol. 2016 Sep 29;3(1):573-589.

  PubMed   |     Download

R.I.P. dead bacteria, you will not be attacked.
Tomé-Poderti L, Saleh MC.
Nat Immunol. 2016 Sep 20;17(10):1138-1140. doi: 10.1038/ni.3562. No abstract available.

  PubMed   |     Download

Virus-derived DNA drives mosquito vector tolerance to arboviral infection.
Goic B, Stapleford KA, Frangeul L, Doucet AJ, Gausson V, Blanc H, Schemmel-Jofre N, Cristofari G, Lambrechts L, Vignuzzi M, Saleh MC.
Nat Commun. 2016 Sep 1;7:12410. doi: 10.1038/ncomms12410.

PubMed   |     Open access from Nat Commun website

piRNA pathway is not required for antiviral defense in Drosophila melanogaster.
Petit M, Mongelli V, Frangeul L, Blanc H, Jiggins F, Saleh MC.
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4218-27. doi:10.1073/pnas.1607952113. Epub 2016 Jun 29.

PubMed   |     Open access from PNAS website

Drosophila cells use nanotube-like structures to transfer dsRNA and RNAi machinery between cells.
Karlikow M, Goic B, Mongelli V, Salles A, Schmitt C, Bonne I, Zurzolo C, Saleh MC.
Sci Rep. 2016 Jun 3;6:27085. doi: 10.1038/srep27085.

PubMed   |     Open access from Sci Rep website

Editorial overview: Host-microbe interactions: viruses: Viral sensing and activation of immunity.
Saleh MC.
Curr Opin Microbiol. 2014 Aug;20:x-xi. doi: 10.1016/j.mib.2014.07.002. Epub 2014 Jul 24.

PubMed   |     ScienceDirect

RNAi and antiviral defense in Drosophila: setting up a systemic immune response.
Karlikow M, Goic B, Saleh MC.

Dev Comp Immunol. 2014 Jan;42(1):85-92. doi: 10.1016/j.dci.2013.05.004. Epub 2013 May 14. Review.

PubMed   |     ScienceDirect

RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila.
Goic B, Vodovar N, Mondotte JA, Monot C, Frangeul L, Blanc H, Gausson V, Vera-Otarola J, Cristofari G, Saleh MC.
Nat Immunol. 2013 Apr;14(4):396-403. doi: 10.1038/ni.2542. Epub 2013 Feb 24.

  PubMed   |     Download

The DNA virus Invertebrate iridescent virus 6 is a target of the Drosophila RNAi machinery.
Bronkhorst AW, van Cleef KW, Vodovar N, Ince IA, Blanc H, Vlak JM, Saleh MC, van Rij RP.
Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):E3604-13. doi: 10.1073/pnas.1207213109. Epub 2012 Nov 14.

PubMed   |     Open access from PNAS website

Living with the enemy: viral persistent infections from a friendly viewpoint.
Goic B, Saleh MC.
Curr Opin Microbiol. 2012 Aug;15(4):531-7. doi: 10.1016/j.mib.2012.06.002. Epub 2012 Jul 5. Review.

PubMed   |     Open access from Curr Opin Microbiol website

Arbovirus-derived piRNAs exhibit a ping-pong signature in mosquito cells.
Vodovar N, Bronkhorst AW, van Cleef KW, Miesen P, Blanc H, van Rij RP, Saleh MC.
PLoS One. 2012;7(1):e30861. doi: 10.1371/journal.pone.0030861. Epub 2012 Jan 24.

PubMed   |     Open access from PLoS ONE website

Of Insects and Viruses: The Role of Small RNAs in Insect Defence.
Vodovar N, Saleh MC.
Advances in Insect Physiology 2012;42: 1-36. doi:10.1016/B978-0-12-387680-5.00001-X

  Science Direct   |     Download

In silico reconstruction of viral genomes from small RNAs improves virus-derived small interfering RNA profiling.
Vodovar N, Goic B, Blanc H, Saleh MC.
J Virol. 2011 Nov;85(21):11016-21. doi: 10.1128/JVI.05647-11. Epub 2011 Aug 31.

PubMed   |     Open access from JVI website

dsRNA uptake in adult Drosophila.
Obadia B, Saleh MC.
Methods Mol Biol. 2011;721:253-63. doi: 10.1007/978-1-61779-037-9_16.

  PubMed   |     Download

Viral small RNA cloning and sequencing.
Gausson V, Saleh MC.
Methods Mol Biol. 2011;721:107-22. doi: 10.1007/978-1-61779-037-9_6.

  PubMed   |     Download

RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila.
Mueller S, Gausson V, Vodovar N, Deddouche S, Troxler L, Perot J, Pfeffer S, Hoffmann JA, Saleh MC, Imler JL.
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19390-5. doi: 10.1073/pnas.1014378107. Epub 2010 Oct 26.

  PubMed   |     Download

Antiviral immunity in Drosophila requires systemic RNA interference spread.
Saleh MC, Tassetto M, van Rij RP, Goic B, Gausson V, Berry B, Jacquier C, Antoniewski C, Andino R.
Nature. 2009 Mar 19;458(7236):346-50. doi: 10.1038/nature07712. Epub 2009 Feb 8.

  PubMed   |     Download

The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster.
van Rij RP, Saleh MC, Berry B, Foo C, Houk A, Antoniewski C, Andino R.
Genes Dev. 2006 Nov 1;20(21):2985-95.

  PubMed   |     Download

The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing.
Saleh MC, van Rij RP, Hekele A, Gillis A, Foley E, O’Farrell PH, Andino R.
Nat Cell Biol. 2006 Aug;8(8):793-802. Epub 2006 Jul 23.

  PubMed   |     Download

RNA silencing in viral infections: insights from poliovirus.
Saleh MC, Van Rij RP, Andino R.
Virus Res. 2004 Jun 1;102(1):11-7. Review.

  PubMed   |     Download

Articles related to our research collaboration with other labs:

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito.
Chelsea Cereghino, Ferdinand Roesch, Lucía Carrau, Alexandra Hardy, Helder V Ribeiro-Filho , Annabelle Henrion-Lacritick, Cassandra Koh, Jeffrey M Marano, Tyler A Bates, Pallavi Rai, Christina Chuong, Shamima Akter , Thomas Vallet, Hervé Blanc, Truitt J Elliott, Anne M Brown, Pawel Michalak, Tanya LeRoith, Jesse D Bloom, Rafael Elias Marques, Maria-Carla Saleh, Marco Vignuzzi, James Weger-Lucarelli.
PLoS Pathogens, 2023, 19 (4), pp.e1010491.

  PubMed   |     Download PDF

RNA recombination at Chikungunya virus 3’UTR as an evolutionary mechanism that provides adaptability.
Filomatori CV, Bardossy ES, Merwaiss F, Suzuki Y, Henrion A, Saleh MC, Alvarez DE.
PLoS Pathog. 2019 Apr 15;15(4):e1007706. doi: 10.1371/journal.ppat.1007706. eCollection 2019 Apr.

PubMed   |     Open access from PLoS Pathogens website

Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes.
Passoni G, Langevin C, Palha N, Mounce BC, Briolat V, Affaticati P, De Job E, Joly JS, Vignuzzi M, Saleh MC, Herbomel P, Boudinot P, Levraud JP.
Dis Model Mech. 2017 Jul 1;10(7):847-857. doi: 10.1242/dmm.029231. Epub 2017 May 8.

PubMed   |     Open access from Dis Model Mech website

Mal de Río Cuarto Virus Infection Triggers the Production of Distinctive Viral-Derived siRNA Profiles in Wheat and Its Planthopper Vector.
de Haro LA, Dumón AD, Mattio MF, Argüello Caro EB, Llauger G, Zavallo D, Blanc H, Mongelli VC, Truol G, Saleh MC, Asurmendi S, Del Vas M.
Front Plant Sci. 2017 May 10;8:766. doi: 10.3389/fpls.2017.00766. eCollection 2017.

PubMed   |     Open Access from Front Plant Sci website

Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity.
Soler-Bistué A, Mondotte JA, Bland MJ, Val ME, Saleh MC, Mazel D.
PLoS Genet. 2015 Apr 13;11(4):e1005156. doi: 10.1371/journal.pgen.1005156. eCollection 2015.

PubMed   |     Open access from PLoS Genetics website

Novel Drosophila viruses encode host-specific suppressors of RNAi.
van Mierlo JT, Overheul GJ, Obadia B, van Cleef KW, Webster CL, Saleh MC, Obbard DJ, van Rij RP.
PLoS Pathog. 2014 Jul 17;10(7):e1004256. doi: 10.1371/journal.ppat.1004256. eCollection 2014 Jul.

PubMed   |     Open access from PLoS Pathogens website

A long-chain flavodoxin protects Pseudomonas aeruginosa from oxidative stress and host bacterial clearance.
Moyano AJ, Tobares RA, Rizzi YS, Krapp AR, Mondotte JA, Bocco JL, Saleh MC, Carrillo N, Smania AM.
PLoS Genet. 2014 Feb 13;10(2):e1004163. doi: 10.1371/journal.pgen.1004163. eCollection 2014 Feb.

PubMed   |     Open access from PLoS Genetics website

Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models.
Rozen-Gagnon K, Stapleford KA, Mongelli V, Blanc H, Failloux AB, Saleh MC, Vignuzzi M.
PLoS Pathog. 2014 Jan;10(1):e1003877. doi: 10.1371/journal.ppat.1003877. Epub 2014 Jan 16.

PubMed   |     Open access from PLoS Pathogens website

Last updated: March 2024